Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans
نویسندگان
چکیده
منابع مشابه
Successful Desensitization Efavirenz in 8 -year-Old HIV-Positive Child
Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...
متن کاملPlasma concentrations of efavirenz are associated with body weight in HIV-positive individuals.
BACKGROUND Efavirenz is among the most widely used antiretroviral drugs. Increased efavirenz exposure has been associated with CNS side effects and also with the chance of emergence of resistance upon treatment interruptions. The objective of this study was to evaluate factors associated with efavirenz plasma concentrations in a cohort of HIV-infected individuals. METHODS From July 2009 to Ma...
متن کاملAssociation of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study
UNLABELLED BACKGROUND Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. There are contradictory data regarding the association between lopinavir concentrations and changes in lipids. AIM To investigate association...
متن کاملAntiretroviral Therapy, Especially Efavirenz, Is Associated with Low Bone Mineral Density in HIV-Infected South Africans.
PURPOSE We determined the prevalence and correlates of low bone mineral density (BMD) in HIV-infected South Africans as there is a paucity of such data from Africa. METHODS BMD and serum 25-hydroxyvitamin D were measured in HIV-positive participants on antiretroviral therapy (ART) and in those not yet on ART (ART-naïve). RESULTS We enrolled 444 participants [median age 35(IQR: 30, 40) years...
متن کاملPlasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations
Efavirenz-based antiretroviral therapy (ART) has been associated with dyslipidemia and dysglycemia, risk factors for cardiovascular disease. However, the pathogenesis is not well understood. We characterized relationships between plasma efavirenz concentrations and lipid and glucose concentrations in HIV-infected South Africans.Participants on efavirenz-based ART were enrolled into a cross-sect...
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ژورنال
عنوان ژورنال: Southern African Journal of HIV Medicine
سال: 2019
ISSN: 2078-6751,1608-9693
DOI: 10.4102/sajhivmed.v20i1.881